Histopathological findings in rabbits after experimental acute exposure to the Loxosceles intermedia (brown spider) venom
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منابع مشابه
A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. The venom contains several enzymatic toxins. Herein, we describe the cloning, expression, refolding and biological evaluation of a novel brown spider protein characterized as a hyaluronidase. Employing a ...
متن کاملIdentification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia.
The venom of Loxosceles intermedia was investigated for the presence of insecticidal toxins active against Spodoptera frugiperda (Lepdoptera: Noctuidade), an insect that has caused great reductions in corn production in Brazil. A combination of gel filtration (Sephadex G-100) and ion-exchange chromatography (Carboxymethyl Cellulose, CM 52) resulted in four major fractions that were submitted to...
متن کاملBrown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes
Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities. In general, spider venom is rich in biologically active molecules that are useful in experimental protocols for pharmacology, biochemistry, cell biology and immunology, as well as putative tools ...
متن کاملLoxosceles laeta venom in rabbits
5 Guilherme Martins1, Maira Oliveira1, Ana Flávia Botelho1, Conrado Gamba2, Clara Duarte3, 6 Adriane Bicalho1, Geovanni Cassali2, Alfredo Goes2, Carlos Chávez-Olórtegui2, Benito 7 Soto-Blanco1 and Marilia Melo1* 8 9 1 Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas 10 Gerais, Brazil; [email protected] (GM); [email protected] (MO);...
متن کاملIdentification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom.
Injuries caused by brown spiders (Loxosceles genus) are associated with dermonecrotic lesions with gravitational spreading and systemic manifestations. The venom has a complex composition containing many different toxins, of which metalloproteases have been described in many different species of this genus. These toxins may degrade extracellular matrix constituents acting as a spreading factor....
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2003
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.2002.00241.x